Sarah Doore
Assistant Professor
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Teaching Interests
- Virology lecture
- Virology lab (undergraduate)
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Education
- Postdoctoral (2020): Michigan State University, Department of Biochemistry and Molecular Biology.
- Ph.D. (2015) University of Arizona, Department of Plant Pathology and Microbiology.
- B.A. (2007) New College of Florida, Department of Biology.
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Description of Research
The Doore lab is interested in viruses of bacteria—known as bacteriophage or phage—and how they interact with their bacterial hosts. We investigate this at three stages of the infection process: 1) host attachment, when the phage identifies a suitable host cell; 2) middle infection, when the phage genes are expressed; and 3) late infection, when new phage particles are assembled and released upon death of the host. We use a specific type of virus, known as Moogleviruses, to investigate these processes in the human pathogen Shigella flexneri. Approaches include classical genetics, next-generation sequencing, experimental evolution, and cryo-electron microscopy. In addition to S. flexneri-infecting Moogleviruses, we are interested in determining the abundance and diversity of this phage group in other non-model bacteria, including Cronobacter sakazakii and Serratia marcescens.
- Publications
